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KMID : 0371320010600050524
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Journal of the Korean Surgical Society
2001 Volume.60 No. 5 p.524 ~ p.530
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Expression of E-Cadherin and α-Catenin in Patients with Colorectal Cancer
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Kim Tae-Yoon
Kim Sung-Yong
Baek Moo-Jun
Chae Man-Kyu
Lee Moon-Soo
Kim Chang-Jin
Kim Chang-Ho
Song Ok-Pyung
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Abstract
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Purpose: E-cadherin plays a crucial role in cell-cell adhesion in epithelial tissues. The function of E-cadherin is thought to be regulated by its associated cytoplasmic proteins including α-catenin. Recent studies have shown a correlation between decreased E-cadherin and α-catenin expression and tumor invasion and metastasis.
Methods: We conducted an immunohistochemical staining of epithelial (E)-cadherin and α-catenin expression in 129 tissue samples taken from colorectal cancer patients undergoing surgical treatment by the avidin-biotin-peroxidase complex method. We classified tumors into three types according to the expression modality. Cancer cells with strong expression at the cell-cell boundaries were defined as two positive ( );, when the expression was positive, but not concentrated at the cell-cell boundaries and weak, they were defined as one positive ( );, and when the tumor showed no staining, they were defined as negative ( ). The relationships between these three expression types and the clinicopathological features of colorectal cancer were investigated.
Results: The expression type of E-cadherin and -catenin was two positive ( ) in 5 and 20 of the cancer tissue specimens, one positive ( ) in 66 and 56, and negative ( ) in 58 (45%) and 53 (41.1%). Negative expression of E- cadherin and α-catenin were significantly correlated with tumor differentiation, Dukes’stage, and lymph node metastasis of the colorectal cancer patients (P＜0.05).
Conclusion: The expression type of E-cadherin is significantly corretated to that of α-catenin, and the loss of their expression indicates the invasion and metastasis of colorectal cancer. To predict tumor invasion and metastasis in colorectal carcinoma, it is useful to inve
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KEYWORD
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E-cadherin, α-catenin, Immunohistochemistry, Colorectal carcinoma
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